Buprenorphine, benzodiazepines and respiratory depression
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چکیده
منابع مشابه
Buprenorphine, benzodiazepines and respiratory depression.
We assessed the high incidence of pain after injection of methohexitone while conducting recent studies in out-patients using methohexitone and alfentanil. We tried a combination of two methods of solution of mcthohexitone alter reports that the use of normal saline rather than water reduced thc incidence of pain from 42"; to 16",,,' and that pretreatment with lignocaine 10 mg rcduced the incid...
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BACKGROUND The objective of this investigation was to examine the ability of the opioid antagonist naloxone to reverse respiratory depression produced by the mu-opioid analgesic, buprenorphine, in healthy volunteers. The studies were designed in light of the claims that buprenorphine is relatively resistant to the effects of naloxone. METHODS In a first attempt, the effect of an intravenous b...
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A 48-year-old man who had undergone thoracotomy for carcinoma of the middle third of his oesophagus developed severe postoperative respiratory depression following intramuscular ketorolac 30 mg 2 h after 150 micrograms epidural buprenorphine. Summation of analgesia by drugs used in combination can have deleterious respiratory effects.
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BACKGROUND We measured the effect of two weight adjusted i.v. doses (0.2 mg per 70 kg and 0.4 mg per 70 kg) of the potent opioid buprenorphine on analgesia and respiratory depression in healthy volunteers. The aim of the study was to compare buprenorphine's behaviour with respect to the occurrence of ceiling (or apparent maximum) in these typical micro-opioid protein-(MOP) receptor effects. M...
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Buprenorphine is a potent, semi-synthetic opioid analgesic derived from thebaine. The drug displays the characteristics of an agonist at the mu receptors and antagonist at the kappa receptors. Although buprenorphine has shown some pharmacological effects on delta and kappa opioid receptors, the action on the mu receptors appears to be responsible for most of the analgesic effects associated wit...
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ژورنال
عنوان ژورنال: Anaesthesia
سال: 1983
ISSN: 0003-2409
DOI: 10.1111/j.1365-2044.1983.tb12045.x